Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.45 |
| ▸ | GSK3A | P49840 | 3/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | EIF4E | P06730 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912304 | 0.92 | GSK3B (0.38) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL1219415 | 0.92 | GSK3B (0.51) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2908029 | 0.90 | GSK3B (0.37) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2912175 | 0.89 | GSK3B (0.51) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2904015 | 0.89 | GSK3B (0.43) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2910776 | 0.89 | MAPT (0.37) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2906887 | 0.89 | GSK3B (0.43) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2911032 | 0.88 | GSK3B (0.45) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2904891 | 0.87 | GSK3B (0.42) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2907739 | 0.87 | GSK3B (0.42) | GSK3BGSK3ACDK1CCNB2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |