Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 4/20 | 0.36 |
| ▸ | GSK3A | P49840 | 3/20 | 0.36 |
| ▸ | EIF4E | P06730 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | PPOX | P50336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912304 | 0.90 | GSK3B (0.38) | MAPTHTTGSK3BGSK3AEIF4E | |
| SCHEMBL2909502 | 0.90 | GSK3B (0.35) | MAPTHTTGAASERPINE1RAB9A | |
| SCHEMBL2906807 | 0.89 | GSK3B (0.45) | MAPTGSK3BGSK3AEIF4ELMNA | |
| SCHEMBL2908029 | 0.89 | GSK3B (0.37) | AKR1C2AKR1C1GSK3BGSK3AEIF4E | |
| SCHEMBL2911406 | 0.89 | EIF4E (0.37) | MAPTHTTGAAAKR1B1AKR1C4 | |
| SCHEMBL2904400 | 0.88 | ALOX5AP (0.43) | MAPTHTTGAARAB9AGSK3B | |
| SCHEMBL2912014 | 0.88 | ALOX5AP (0.43) | MAPTHTTGAARAB9AGSK3B | |
| SCHEMBL2909381 | 0.88 | MAPT (0.38) | MAPTHTTGAASERPINE1RAB9A | |
| SCHEMBL2907210 | 0.88 | MAPT (0.38) | MAPTHTTGAASERPINE1RAB9A | |
| SCHEMBL2906887 | 0.84 | GSK3B (0.43) | HTTGSK3BGSK3AEIF4ECDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |