Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | LEF1 | Q9UJU2 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913384 | 0.94 | NR1H4 (0.40) | NR1H4ITGA4L3MBTL1DHODHF10 | |
| SCHEMBL2915054 | 0.90 | NR1H4 (0.40) | NR1H4ITGA4L3MBTL1DHODHF10 | |
| SCHEMBL2913600 | 0.90 | NR1H4 (0.40) | NR1H4ITGA4L3MBTL1DHODHF10 | |
| SCHEMBL2909795 | 0.89 | NR1H4 (0.39) | NR1H4ITGA4L3MBTL1DHODHF10 | |
| SCHEMBL2917122 | 0.88 | MAPT (0.42) | NR1H4ITGA4L3MBTL1DHODHF10 | |
| SCHEMBL2907824 | 0.87 | MAPT (0.39) | NR1H4ITGA4L3MBTL1RXFP1MAPT | |
| SCHEMBL2910598 | 0.86 | NR1H4 (0.56) | NR1H4MAPTSMN1; SMN2KDM4EPOLB | |
| SCHEMBL2910755 | 0.85 | MAPT (0.38) | NR1H4ITGA4L3MBTL1DHODHF10 | |
| SCHEMBL2913332 | 0.84 | SMN1; SMN2 (0.41) | NR1H4ITGA4L3MBTL1DHODHF10 | |
| SCHEMBL2916146 | 0.84 | ALDH1A1 (0.38) | NR1H4ITGA4L3MBTL1DHODHF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |