Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | PDE5A | O76074 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2909195 | 0.83 | ABCB1 (0.52) | ABCB1ABCG2PTGS2PDE5AKDM4E | |
| SCHEMBL13309934 | 0.83 | ABCB1 (0.62) | ABCB1ABCG2PTGS2PDE5ARAB9A | |
| SCHEMBL16392006 | 0.80 | ABCG2 (0.79) | ABCB1ABCG2PTGS2PDE5ARAB9A | |
| SCHEMBL2907007 | 0.78 | ABCB1 (0.58) | ABCB1ABCG2PDE5ARAB9AKDM4E | |
| SCHEMBL2905528 | 0.76 | ABCG2 (0.44) | ABCB1ABCG2NPC1KMT2AADORA2A | |
| SCHEMBL12923510 | 0.76 | MAPT (0.47) | ABCB1ABCG2PDE5AKDM4ELMNA | |
| SCHEMBL2903558 | 0.73 | ADORA2A (0.54) | KDM4ELMNAMAPK1KMT2AADORA2A | |
| SCHEMBL27827798 | 0.73 | ABCG2 (0.60) | ABCB1ABCG2RAB9ANPC1KMT2A | |
| SCHEMBL2905601 | 0.72 | ADORA1 (0.45) | PTGS2KMT2AADORA2AADORA1ALDH1A1 | |
| SCHEMBL27846476 | 0.71 | SCN9A (0.55) | KMT2AADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217606-A1 | SOLUBILIZED THIAZOLOPYRIDINES | Sirtris Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061453-A1 | SOLUBILIZED THIAZOLOPYRIDINES | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |