Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.56 |
| ▸ | MET | P08581 | 8/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.56 |
| ▸ | AURKA | O14965 | 5/20 | 0.56 |
| ▸ | TEK | Q02763 | 5/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | AXL | P30530 | 4/20 | 0.54 |
| ▸ | MERTK | Q12866 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 3/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.48 |
| ▸ | FLT4 | P35916 | 2/20 | 0.48 |
| ▸ | PDXK | O00764 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.48 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1890635 | 0.86 | AXL (0.65) | KDRMETAURKBAURKATEK | |
| SCHEMBL29558136 | 0.86 | AXL (0.65) | KDRMETAURKBAURKATEK | |
| SCHEMBL29073430 | 0.85 | KDR (0.52) | KDRMETAURKBAURKATEK | |
| SCHEMBL29073385 | 0.83 | AXL (0.59) | KDRMETAURKBAURKATEK | |
| SCHEMBL21753513 | 0.82 | PDGFRB (0.59) | KDRPDGFRBFGFR2PDGFRASRC | |
| SCHEMBL30106512 | 0.82 | PDGFRB (0.59) | KDRPDGFRBFGFR2PDGFRASRC | |
| SCHEMBL1132601 | 0.82 | AXL (0.60) | KDRMETAURKBAURKATEK | |
| SCHEMBL29487165 | 0.82 | AXL (0.60) | KDRMETAURKBAURKATEK | |
| SCHEMBL1132368 | 0.82 | AXL (0.51) | KDRMETAURKBAURKATEK | |
| SCHEMBL1132598 | 0.79 | AXL (0.62) | KDRMETAURKBAURKATEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116783166-B | Dicarboxamide compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2025-01-14 | — | — | CN | disclosed |
| CN-116783166-A | Dicarboxamide compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-09-19 | — | — | CN | disclosed |
| WO-2022161447-A1 | DICARBOXAMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2022-08-04 | — | — | WO | disclosed |