Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 2/20 | 0.52 |
| ▸ | BRD4 | O60885 | 5/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.39 |
| ▸ | YAP1 | P46937 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | F13A1 | P00488 | 1/20 | 0.37 |
| ▸ | TGM1 | P22735 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29074749 | 0.83 | TGM2 (0.56) | TGM2BRD4EGFRKDREPHB4 | |
| SCHEMBL30063457 | 0.81 | AKR1C3 (0.49) | KMT2AAKR1C3AKR1C2TEAD1YAP1 | |
| SCHEMBL21054160 | 0.81 | AKR1C3 (0.49) | KMT2AAKR1C3AKR1C2TEAD1YAP1 | |
| SCHEMBL25312072 | 0.81 | TEAD1 (0.61) | TGM2BRD4EGFRKDRFYN | |
| SCHEMBL25314161 | 0.80 | TGM2 (0.52) | TGM2BRD4EGFRKDREPHB4 | |
| SCHEMBL31097825 | 0.78 | TGM2 (0.53) | TGM2EGFRKDREPHB4FYN | |
| SCHEMBL25314332 | 0.78 | TGM2 (0.53) | TGM2EGFRKDREPHB4FYN | |
| SCHEMBL21054279 | 0.78 | MYC (0.45) | KMT2AKDRAKR1C3AKR1C2TEK | |
| SCHEMBL27197657 | 0.78 | KMT2A (0.43) | EGFRKMT2ATEAD1YAP1 | |
| SCHEMBL29074769 | 0.78 | TGM2 (0.52) | TGM2BRD4EGFRKDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116761795-A | Inhibitors of Transcription Enhancement Associated Domain (TEAD) and uses thereof | 达纳-法伯癌症研究所股份有限公司 | 2023-09-15 | — | — | CN | disclosed |