Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 8/20 | 0.48 |
| ▸ | FLT3 | P36888 | 4/20 | 0.48 |
| ▸ | MERTK | Q12866 | 4/20 | 0.48 |
| ▸ | GAS6 | Q14393 | 4/20 | 0.48 |
| ▸ | AXL | P30530 | 3/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 3/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | SELP | P16109 | 4/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31612072 | 1.00 | TYRO3 (0.48) | TYRO3FLT3MERTKGAS6AXL | |
| SCHEMBL31612059 | 0.96 | LCK (0.46) | TYRO3FLT3MERTKGAS6AXL | |
| SCHEMBL31612108 | 0.95 | TYRO3 (0.50) | TYRO3FLT3MERTKGAS6AXL | |
| SCHEMBL29076324 | 0.95 | TYRO3 (0.50) | TYRO3FLT3MERTKGAS6AXL | |
| SCHEMBL31612058 | 0.91 | TYRO3 (0.47) | TYRO3FLT3MERTKGAS6AXL | |
| SCHEMBL31612101 | 0.91 | TYRO3 (0.48) | TYRO3FLT3MERTKGAS6AXL | |
| SCHEMBL31612116 | 0.87 | LCK (0.48) | TYRO3FLT3MERTKGAS6AXL | |
| SCHEMBL31612105 | 0.86 | LCK (0.60) | CHRNA7LCKMAPK14EGFR | |
| SCHEMBL29076139 | 0.86 | LCK (0.60) | CHRNA7LCKMAPK14EGFR | |
| SCHEMBL30962894 | 0.84 | CHRNA7 (0.48) | CHRNA7MEN1MAPTKMT2AKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116514726-A | Pyrimidine derivative and application thereof | 四川大学 | 2023-08-01 | — | — | CN | disclosed |