Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF18A | Q8NI77 | 16/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31032571 | 0.88 | KIF18A (0.55) | KIF18ASCN10A | |
| SCHEMBL22122582 | 0.87 | KIF18A (0.71) | KIF18A | |
| SCHEMBL29367667 | 0.87 | KIF18A (0.71) | KIF18A | |
| SCHEMBL30522474 | 0.87 | KIF18A (0.51) | KIF18ASCN10A | |
| SCHEMBL31500866 | 0.87 | KIF18A (0.49) | KIF18ASCN10A | |
| SCHEMBL29076088 | 0.84 | KIF18A (0.58) | KIF18A | |
| SCHEMBL31500868 | 0.83 | KIF18A (0.51) | KIF18ASCN10A | |
| SCHEMBL29076071 | 0.82 | KIF18A (0.63) | KIF18A | |
| SCHEMBL30547911 | 0.82 | KIF18A (0.63) | KIF18A | |
| SCHEMBL30788676 | 0.81 | KIF18A (0.53) | KIF18A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116789637-B | Kinesin KIF18A inhibitor and application thereof | 上海湃隆生物科技有限公司 | 2024-08-02 | — | — | CN | disclosed |
| CN-116789637-A | Kinesin KIF18A inhibitor and application thereof | 上海湃隆生物科技有限公司 | 2023-09-22 | — | — | CN | disclosed |