Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 7/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 4/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30881935 | 0.96 | PGR (0.46) | PGRAKR1B1BACE1TNKSTNKS2 | |
| SCHEMBL29621945 | 0.93 | AKR1B1 (0.44) | PGRAKR1B1BACE1TNKSTNKS2 | |
| SCHEMBL24455096 | 0.93 | AKR1B1 (0.44) | PGRAKR1B1BACE1TNKSTNKS2 | |
| SCHEMBL3257846 | 0.86 | BACE1 (0.51) | PGRAKR1B1BACE1TNKSTNKS2 | |
| SCHEMBL23778287 | 0.86 | MEN1 (0.42) | PGRAKR1B1BACE1TNKSTNKS2 | |
| SCHEMBL6635806 | 0.84 | BACE1 (0.50) | PGRAKR1B1BACE1TNKSTNKS2 | |
| Hydrochloric Acid SCHEMBL6641764 | 0.83 | BACE1 (0.49) | PGRAKR1B1BACE1TNKSTNKS2 | |
| Hydrochloric Acid SCHEMBL6747887 | 0.83 | BACE1 (0.49) | PGRAKR1B1BACE1TNKSTNKS2 | |
| SCHEMBL30667191 | 0.81 | AKR1B1 (0.37) | PGRAKR1B1BACE1CREBBPBRD4 | |
| SCHEMBL16687077 | 0.80 | PGR (0.50) | PGRAKR1B1BACE1TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025090514-A1 | COVALENT SARM1 INHIBITORS | NURA BIO, INC. (US) | 2025-05-01 | — | — | WO | disclosed |
| CN-116802176-A | Oxindoles and methods of use thereof | 阿利戈斯治疗公司 | 2023-09-22 | — | — | CN | disclosed |
| EP-4240722-A1 | OXINDOLES AND METHODS OF USE THEREOF | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022099066-A1 | OXINDOLES AND METHODS OF USE THEREOF | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |