Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.71 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.71 |
| ▸ | CSF1R | P07333 | 12/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1276321 | 0.91 | KCNH2 (0.85) | KCNH2SCN5ACSF1R | |
| SCHEMBL2904920 | 0.90 | KCNH2 (0.74) | KCNH2SCN5ACSF1RPDE4B | |
| SCHEMBL2910054 | 0.90 | KCNH2 (0.74) | KCNH2SCN5ACSF1RPDE4B | |
| SCHEMBL2913343 | 0.89 | KCNH2 (0.72) | KCNH2SCN5ACSF1RPDE4B | |
| SCHEMBL2910958 | 0.89 | KCNH2 (0.72) | KCNH2SCN5ACSF1RPDE4B | |
| SCHEMBL2911041 | 0.87 | CSF1R (0.61) | KCNH2SCN5ACSF1R | |
| SCHEMBL2911635 | 0.86 | KCNH2 (0.83) | KCNH2SCN5ACSF1R | |
| SCHEMBL27744636 | 0.86 | KCNH2 (0.68) | KCNH2SCN5ACSF1RPDE4B | |
| SCHEMBL2911562 | 0.86 | KCNH2 (0.73) | KCNH2SCN5ACSF1R | |
| SCHEMBL2910639 | 0.85 | CSF1R (0.77) | KCNH2SCN5ACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |
| CN-101466682-A | 4-anilinoquinolina-3-carboxamidas como inhibidores de la quinasa CSF-1R | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | disclosed |