Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.63 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.63 |
| ▸ | CSF1R | P07333 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MC4R | P32245 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912075 | 0.93 | KCNH2 (0.61) | KCNH2SCN5ACSF1RMAPTGAA | |
| SCHEMBL1276767 | 0.92 | KCNH2 (0.74) | KCNH2SCN5ACSF1R | |
| SCHEMBL2907152 | 0.91 | KCNH2 (0.75) | KCNH2SCN5ACSF1RMAPTGAA | |
| SCHEMBL2912181 | 0.91 | KCNH2 (0.65) | KCNH2SCN5ACSF1RMAPTGAA | |
| SCHEMBL2912835 | 0.90 | KCNH2 (0.63) | KCNH2SCN5ACSF1RMAPTGAA | |
| SCHEMBL2914184 | 0.89 | CSF1R (0.70) | KCNH2SCN5ACSF1RMAPTLMNA | |
| SCHEMBL2913052 | 0.89 | KCNH2 (0.71) | KCNH2SCN5ACSF1RMAPTGAA | |
| SCHEMBL2909522 | 0.88 | KCNH2 (0.69) | KCNH2SCN5ACSF1RMAPTGAA | |
| SCHEMBL2910088 | 0.87 | KCNH2 (0.61) | KCNH2SCN5ACSF1RMAPTGAA | |
| SCHEMBL2910312 | 0.87 | KCNH2 (0.60) | KCNH2SCN5ACSF1RMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |