Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.69 |
| ▸ | SCN5A | Q14524 | 10/20 | 0.63 |
| ▸ | CSF1R | P07333 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912075 | 0.94 | KCNH2 (0.61) | KCNH2SCN5ACSF1RMEN1LMNA | |
| SCHEMBL2910626 | 0.92 | KCNH2 (0.74) | KCNH2SCN5ACSF1RMEN1GAA | |
| SCHEMBL1276774 | 0.91 | KCNH2 (0.82) | KCNH2SCN5ACSF1R | |
| SCHEMBL2911755 | 0.91 | KCNH2 (0.83) | KCNH2SCN5ACSF1RMEN1LMNA | |
| SCHEMBL2907901 | 0.88 | KCNH2 (0.63) | KCNH2SCN5ACSF1RMEN1LMNA | |
| SCHEMBL2914184 | 0.88 | CSF1R (0.70) | KCNH2SCN5ACSF1RLMNAMAPT | |
| SCHEMBL2909554 | 0.87 | CSF1R (0.67) | KCNH2SCN5ACSF1R | |
| SCHEMBL2904820 | 0.86 | CSF1R (0.73) | KCNH2SCN5ACSF1RMEN1GAA | |
| SCHEMBL2909768 | 0.86 | KCNH2 (0.65) | KCNH2SCN5ACSF1RMEN1LMNA | |
| SCHEMBL2914338 | 0.85 | KCNH2 (0.73) | KCNH2SCN5ACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |