Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 0.59 |
| ▸ | CCNE1 | P24864 | 15/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 15/20 | 0.59 |
| ▸ | CDK9 | P50750 | 3/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.54 |
| ▸ | CDK7 | P50613 | 2/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.54 |
| ▸ | CCNH | P51946 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 6/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2907947 | 1.00 | CDK2 (0.59) | CDK2CCNE1CDK5CDK9CDK5R1 | |
| SCHEMBL2914183 | 0.84 | CDK2 (0.53) | CDK2CCNE1CDK5CDK9CDK5R1 | |
| SCHEMBL2907954 | 0.84 | CDK2 (0.45) | CDK2CCNE1CDK5CDK9CDK5R1 | |
| SCHEMBL2911930 | 0.75 | CCNE1 (0.56) | CDK2CCNE1CDK5CDK9CDK5R1 | |
| SCHEMBL2912269 | 0.71 | CDK2 (0.65) | CDK2CCNE1CDK5CDK9CDK5R1 | |
| SCHEMBL2913193 | 0.70 | CDK2 (1.00) | CDK2CCNE1CDK5CDK9CDK5R1 | |
| SCHEMBL2913185 | 0.70 | CDK2 (1.00) | CDK2CCNE1CDK5CDK9CDK5R1 | |
| SCHEMBL2913249 | 0.69 | CDK2 (0.68) | CDK2CCNE1CDK5CDK9CDK5R1 | |
| SCHEMBL6016588 | 0.69 | CDK1 (0.71) | CDK2CCNE1CDK5CDK9CDK5R1 | |
| SCHEMBL6016540 | 0.69 | CDK1 (0.71) | CDK2CCNE1CDK5CDK9CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1348707-B1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | USTAV EX BOTAN AV CR V V I I O (CZ) | 2010-08-25 | — | — | EP | disclosed |
| EP-1348707-A1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | Ustav Experimentalni Botaniky AV CR (Institute of Experimental Botany Academy of Sciences of the Czech Republic) (CZ) | 2003-10-01 | — | — | EP | disclosed |