Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 18/20 | 0.68 |
| ▸ | CCNE1 | P24864 | 15/20 | 0.68 |
| ▸ | CDK5 | Q00535 | 14/20 | 0.68 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.68 |
| ▸ | CDK9 | P50750 | 3/20 | 0.68 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.68 |
| ▸ | CDK7 | P50613 | 2/20 | 0.68 |
| ▸ | CCNH | P51946 | 1/20 | 0.68 |
| ▸ | CDK1 | P06493 | 5/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.60 |
| ▸ | CDK4 | P11802 | 2/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.60 |
| ▸ | CCND1 | P24385 | 2/20 | 0.60 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.60 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.59 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910732 | 0.89 | CDK2 (0.67) | CDK2CCNE1CDK5CDK5R1CDK9 | |
| SCHEMBL2912811 | 0.88 | CDK2 (0.64) | CDK2CCNE1CDK5CDK5R1CDK9 | |
| SCHEMBL2910993 | 0.87 | CDK2 (0.75) | CDK2CCNE1CDK5CDK5R1CDK9 | |
| SCHEMBL2912269 | 0.82 | CDK2 (0.65) | CDK2CCNE1CDK5CDK5R1CDK9 | |
| SCHEMBL2910610 | 0.82 | CDK2 (0.49) | CDK2CCNE1CDK5CDK5R1CDK9 | |
| SCHEMBL2913251 | 0.82 | CDK1 (0.58) | CDK2CCNE1CDK5CDK5R1CDK9 | |
| SCHEMBL2913193 | 0.81 | CDK2 (1.00) | CDK2CCNE1CDK5CDK5R1CDK9 | |
| SCHEMBL2913185 | 0.81 | CDK2 (1.00) | CDK2CCNE1CDK5CDK5R1CDK9 | |
| SCHEMBL2911502 | 0.79 | CDK1 (0.67) | CDK2CCNE1CDK5CDK5R1CDK9 | |
| SCHEMBL3725652 | 0.79 | CDK2 (0.62) | CDK2CCNE1CDK5CDK5R1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1348707-B1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | USTAV EX BOTAN AV CR V V I I O (CZ) | 2010-08-25 | — | — | EP | disclosed |
| EP-1348707-A1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | Ustav Experimentalni Botaniky AV CR (Institute of Experimental Botany Academy of Sciences of the Czech Republic) (CZ) | 2003-10-01 | — | — | EP | disclosed |