Succinic Acid

Succinic Acid

SCHEMBL2907967

NCCNCCO.O=C(O)CCC(=O)O.O=C(O)CCC(=O)O

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 known ✓ P23975 1/20 0.44
LMNA P02545 6/20 0.48
KMT2A Q03164 3/20 0.48
THRB P10828 2/20 0.48
BLM P54132 2/20 0.48
NPSR1 Q6W5P4 2/20 0.48
GABRR1 P24046 2/20 0.48
GABRR3 A8MPY1 1/20 0.48
GABRP O00591 1/20 0.48
GABRD O14764 1/20 0.48
HDAC3 O15379 1/20 0.48
GABBR2 O75899 1/20 0.48
CYP1A2 P05177 1/20 0.48
GABRA1 P14867 1/20 0.48
TSHR P16473 1/20 0.48
GABRB1 P18505 1/20 0.48
GABRG2 P18507 1/20 0.48
GABRB3 P28472 1/20 0.48
GABRR2 P28476 1/20 0.48
SLC6A1 P30531 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Succinic Acid SCHEMBL6650682 1.00 LMNA (0.48) LMNAKMT2ATHRBBLMNPSR1
Beta-Alanine SCHEMBL17957373 0.93 LMNA (0.46) LMNAKMT2ATHRBBLMNPSR1
Succinic Acid SCHEMBL3778716 0.91 LMNA (0.57) LMNAKMT2ATHRBBLMNPSR1
Succinic Acid SCHEMBL2449729 0.91 LMNA (0.57) LMNAKMT2ATHRBBLMNPSR1
Trientine SCHEMBL505672 0.88 LMNA (0.58) LMNAKMT2ATHRBBLMNPSR1
Succinic Acid SCHEMBL2447637 0.88 LMNA (0.58) LMNAKMT2ATHRBBLMNPSR1
Bicarbonate SCHEMBL7190430 0.88 CA12 (0.53) LMNAKMT2ATHRBBLMNPSR1
Trientine SCHEMBL14343015 0.88 LMNA (0.58) LMNAKMT2ATHRBBLMNPSR1
Trientine SCHEMBL506363 0.88 LMNA (0.58) LMNAKMT2ATHRBBLMNPSR1
Succinic Acid SCHEMBL18492331 0.88 EGLN1 (0.53) LMNAGABRR1TSHRNFKB1CAMK2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0783034-B1 Chelating agent and detergent comprising the same MITSUBISHI RAYON CO (JP) 2010-08-18 EP disclosed
US-6451757-B2 ASPARTIC ACID, MALEIC ACID, ACRYLIC ACID, MALIC ACID, GLYCINE, GLYCOLIC ACID, IMINODIACETIC ACID, NITRILOTRIACETIC ACID, ALPHA-ALANINE, BETA-ALANINE, IMINODIPROPIONIC ACID, FUMARIC ACID, A SYNTHETIC AMINO ACID; BIODEGRADABLE MITSUBISHI RAYON CO., LTD. (JP) 2002-09-17 US disclosed
US-6426229-B1 ASPARTIC, MALEIC, ACRYLIC, MALIC, GLYCINE, GLYCOLIC,IMINODIACETIC, NITRILOTRIACETIC,BETA-ALANINE, IMINODIPROPIONIC, AND FUMARIC ACIDS, SYNTHETIC STARTING AND INTERMEDIATE AMINO ACIDS; BIODEGRADAABLE MITSUBISHI RAYON CO., LTD. (JP) 2002-07-30 US disclosed
US-20020039980-A1 Chelating agent and detergent comprising the same MITSUBISHI RAYON CO., LTD. 2002-04-04 US disclosed
US-20010034318-A1 Chelating agent and detergent comprising the same NITTO CHEMICAL INDUSTRY CO., LTD (NAME CHANGED TO MITSUBISHI RAYON CO., LTD.) 2001-10-25 US disclosed
US-6221834-B1 (S)-ASPARTIC ACID-N,N-DIACETIC ACID (ASDA) OR ALKALI METAL SALTS OR AMMONIA SALTS THEREOF AND (II) ASPARTIC ACID, MALIC ACID, IMINODIACETIC ACID (IDA), NITRILOTRIACETIC ACID (NTA) OR FUMARIC ACID MITSUBISHI RAYON CO., LTD. (JP) 2001-04-24 US disclosed
EP-0783034-A2 Chelating agent and detergent comprising the same NITTO CHEMICAL INDUSTRY CO., LTD. (JP) 1997-07-09 EP disclosed