Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.36 |
| ▸ | MET | P08581 | 8/20 | 0.33 |
| ▸ | KDR | P35968 | 5/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | MST1R | Q04912 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | YES1 | P07947 | 1/20 | 0.30 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.30 |
| ▸ | LTK | P29376 | 1/20 | 0.30 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25040845 | 0.86 | ESR1 (0.30) | ESR1ESR2 | |
| SCHEMBL31048910 | 0.84 | — | — | |
| SCHEMBL31618756 | 0.84 | — | — | |
| SCHEMBL29080149 | 0.84 | — | — | |
| SCHEMBL25335156 | 0.82 | MET (0.32) | METKDRSRCFGFR2AXL | |
| SCHEMBL25348854 | 0.78 | — | — | |
| SCHEMBL29680425 | 0.76 | MET (0.38) | ESR1ESR2METKDRSRC | |
| SCHEMBL32660863 | 0.76 | ADORA2A (0.33) | ESR2 | |
| SCHEMBL29080071 | 0.76 | ADORA2A (0.33) | ESR2 | |
| SCHEMBL23042977 | 0.75 | CYP3A4 (0.41) | ESR1ESR2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116829151-A | Azaquinazoline pan KRAS inhibitors | 米拉蒂治疗股份有限公司 | 2023-09-29 | — | — | CN | disclosed |