Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 16/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | IRF3 | Q14653 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL29791230 | 1.00 | STING1 (0.56) | STING1CYP3A4IRF3ATM | |
| Bromide SCHEMBL30615794 | 1.00 | STING1 (0.56) | STING1CYP3A4IRF3ATM | |
| SCHEMBL26772068 | 0.99 | STING1 (0.57) | STING1CYP3A4IRF3ATM | |
| SCHEMBL22925517 | 0.92 | STING1 (0.65) | STING1CYP3A4 | |
| SCHEMBL22121522 | 0.92 | STING1 (0.65) | STING1CYP3A4 | |
| SCHEMBL22121394 | 0.82 | KDM4E (0.47) | STING1CYP3A4 | |
| SCHEMBL23077541 | 0.82 | STING1 (0.57) | STING1CYP3A4 | |
| SCHEMBL23095398 | 0.81 | STING1 (0.54) | STING1CYP3A4 | |
| SCHEMBL29437070 | 0.81 | STING1 (0.54) | STING1CYP3A4 | |
| SCHEMBL25098724 | 0.81 | STING1 (0.68) | STING1CYP3A4ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116829551-A | Immunomodulatory antibody drug conjugates | 思进公司 | 2023-09-29 | — | — | CN | disclosed |