Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 3/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29477860 | 1.00 | MAPKAPK2 (0.37) | MAPKAPK2CA12CA1CA9MAP4K4 | |
| SCHEMBL30469723 | 0.88 | PTPN11 (0.43) | MAPKAPK2CA12CA1CA9MAP4K4 | |
| SCHEMBL29346060 | 0.88 | CA12 (0.38) | MAPKAPK2CA12CA1CA9MAP4K4 | |
| SCHEMBL24364158 | 0.88 | PTPN11 (0.43) | MAPKAPK2CA12CA1CA9MAP4K4 | |
| SCHEMBL29344652 | 0.87 | CA12 (0.37) | MAPKAPK2CA12CA1CA9MAP4K4 | |
| SCHEMBL24364781 | 0.86 | MAPKAPK2 (0.39) | MAPKAPK2MAP4K4PRMT1RORCSYK | |
| SCHEMBL31590994 | 0.84 | MAPT (0.45) | RORC | |
| SCHEMBL24364159 | 0.80 | AR (0.37) | MAPKAPK2LCKRORCSYK | |
| SCHEMBL30469640 | 0.80 | AR (0.37) | MAPKAPK2LCKRORCSYK | |
| SCHEMBL24364156 | 0.80 | MAPKAPK2 (0.40) | MAPKAPK2CA12CA1CA9MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116568677-A | piperidin-1-yl-N-pyridin-3-yl-2-oxoacetamide derivatives useful for the treatment of MTAP deficiency and/or MTA accumulating cancers | 探戈医药股份有限公司 | 2023-08-08 | — | — | CN | disclosed |