Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 3/20 | 0.39 |
| ▸ | CLK2 | P49760 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2908345 | 1.00 | RAB9A (0.46) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2908184 | 0.88 | RAB9A (0.45) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2908188 | 0.88 | RAB9A (0.45) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2905168 | 0.80 | NPC1 (0.39) | RAB9ANPC1SMN1; SMN2TSHRNPY5R | |
| SCHEMBL2905170 | 0.80 | NPC1 (0.39) | RAB9ANPC1SMN1; SMN2TSHRNPY5R | |
| SCHEMBL2907472 | 0.77 | NPC1 (0.36) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2907471 | 0.77 | NPC1 (0.36) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2906700 | 0.77 | NPC1 (0.37) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2906701 | 0.77 | NPC1 (0.37) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2908795 | 0.75 | NPC1 (0.42) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076495-B1 | QUINOLINE DERIVATIVES WITH 5-HT-BINDING PROPERTIES | HOFFMANN LA ROCHE (CH) | 2010-08-18 | — | — | EP | disclosed |