Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.51 |
| ▸ | PLK1 | P53350 | 4/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29084072 | 0.94 | EGFR (0.54) | EGFRPLK1LRRK2ALKAURKA | |
| SCHEMBL29083976 | 0.91 | LRRK2 (0.46) | EGFRPLK1LRRK2ALKIGF1R | |
| SCHEMBL29084097 | 0.89 | EGFR (0.56) | EGFRPLK1LRRK2ALKAURKA | |
| SCHEMBL29083968 | 0.89 | ALK (0.44) | EGFRPLK1LRRK2ALKAURKA | |
| SCHEMBL29084049 | 0.88 | ULK1 (0.48) | EGFRLRRK2ALKINSRIGF1R | |
| SCHEMBL29084091 | 0.88 | EGFR (0.53) | EGFRPLK1ALKINSRIGF1R | |
| SCHEMBL29084035 | 0.86 | EGFR (0.64) | EGFRPLK1ALK | |
| SCHEMBL29084010 | 0.86 | EGFR (0.46) | EGFRPLK1LRRK2ALKINSR | |
| SCHEMBL29084087 | 0.85 | EGFR (0.44) | EGFRPLK1LRRK2ALK | |
| SCHEMBL29974779 | 0.85 | EGFR (0.42) | EGFRLRRK2ALKIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670127-A | EGFR inhibitors and compositions and uses thereof | 贝达药业股份有限公司 | 2023-08-29 | — | — | CN | claimed |
| WO-2022206797-A1 | EGFR INHIBITOR, AND COMPOSITION AND USE THEREOF | 贝达药业股份有限公司 | 2022-10-06 | — | — | WO | claimed |
| CN-116670127-A | EGFR inhibitors and compositions and uses thereof | 贝达药业股份有限公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2022206797-A1 | EGFR INHIBITOR, AND COMPOSITION AND USE THEREOF | 贝达药业股份有限公司 | 2022-10-06 | — | — | WO | disclosed |