Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.53 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.53 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 3/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 13/20 | 0.43 |
| ▸ | P2RX2 | Q9UBL9 | 13/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3062134 | 0.87 | CACNA1I (0.70) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL1057087 | 0.81 | CACNA1I (0.71) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL3064509 | 0.80 | CACNA1I (0.56) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL3058080 | 0.79 | CACNA1I (0.55) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL1062015 | 0.79 | CACNA1I (0.69) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL2908420 | 0.75 | CACNA1I (0.52) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL3042966 | 0.72 | CACNA1I (0.49) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL2138961 | 0.70 | CACNA1I (0.55) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL2138971 | 0.70 | CACNA1I (0.55) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL23327963 | 0.69 | CACNA1I (1.00) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212291-B1 | HETEROCYCLE PHENYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK SHARP & DOHME (US) | 2014-06-04 | — | — | EP | claimed |
| US-8637513-B2 | Heterocycle phenyl amide T-type calcium channel antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-01-28 | — | — | US | claimed |
| US-20100261724-A1 | HETEROCYCLE PHENYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-10-14 | — | — | US | claimed |
| EP-2212291-B1 | HETEROCYCLE PHENYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK SHARP & DOHME (US) | 2014-06-04 | — | — | EP | disclosed |
| US-8637513-B2 | Heterocycle phenyl amide T-type calcium channel antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-01-28 | — | — | US | disclosed |
| US-20100261724-A1 | HETEROCYCLE PHENYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-10-14 | — | — | US | disclosed |
| EP-2212291-A1 | HETEROCYCLE PHENYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009054984-A1 | HETEROCYCLE PHENYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261724-A1 | HETEROCYCLE PHENYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | CACNA1G, CACNA1H, CACNA1I | CACNA1I 3/4885CACNA1G 1/4885CACNA1H 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.