Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.51 |
| ▸ | DRD2 | P14416 | 5/20 | 0.51 |
| ▸ | HTR1A | P08908 | 5/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR1E | P28566 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR5A | P47898 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 4/20 | 0.43 |
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | DRD5 | P21918 | 4/20 | 0.43 |
| ▸ | QDPR | P09417 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10078852 | 0.83 | DRD2 (0.51) | DRD3DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL15829965 | 0.81 | DRD2 (0.60) | DRD3DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL13416045 | 0.80 | DRD2 (0.51) | DRD3DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL9230752 | 0.80 | DRD2 (0.64) | DRD3DRD2HTR1AHTR2CHTR2B | |
| SCHEMBL610093 | 0.80 | DRD3 (0.48) | DRD3DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL15965587 | 0.78 | DRD3 (0.47) | DRD3DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL6198518 | 0.78 | DRD2 (0.55) | DRD3DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL6200948 | 0.78 | DRD2 (0.55) | DRD3DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL826215 | 0.78 | DRD2 (0.55) | DRD3DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL23251067 | 0.78 | DRD3 (0.49) | DRD3DRD2HTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220075-A1 | INDOLE COMPOUNDS AND METHODS FOR TREATING VISCERAL PAIN | Neuraxon, INC. (CA) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009062319-A1 | INDOLE COMPOUNDS AND METHODS FOR TREATING VISCERAL PAIN | NEURAXON, INC. (CA) | 2009-05-22 | — | — | WO | disclosed |