Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 9/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 6/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.38 |
| ▸ | CDK9 | P50750 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.36 |
| ▸ | FLT3 | P36888 | 4/20 | 0.36 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.35 |
| ▸ | CDK7 | P50613 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29088974 | 0.86 | NTRK1 (0.40) | NTRK1NTRK3NTRK2CCNT1CDK9 | |
| SCHEMBL29088901 | 0.84 | NTRK1 (0.38) | NTRK1NTRK3NTRK2CCNT1CDK9 | |
| SCHEMBL29088983 | 0.83 | NPC1 (0.40) | NTRK1NTRK3NTRK2CCNT1CDK9 | |
| SCHEMBL16946723 | 0.82 | NTRK1 (0.50) | NTRK1NTRK3NTRK2SMPD3 | |
| SCHEMBL21229436 | 0.82 | SMPD3 (0.55) | NTRK1NTRK3NTRK2SMPD3 | |
| SCHEMBL29088904 | 0.81 | NTRK1 (0.37) | NTRK1NTRK3NTRK2ALDH1A1MAPT | |
| SCHEMBL29511265 | 0.78 | NTRK1 (0.49) | NTRK1NTRK3NTRK2ALDH1A1MAPT | |
| SCHEMBL30512201 | 0.75 | CCNT1 (0.32) | NTRK1NTRK3NTRK2CCNT1CDK9 | |
| SCHEMBL21229423 | 0.75 | NTRK1 (0.51) | NTRK1NTRK3NTRK2 | |
| SCHEMBL29289506 | 0.75 | NTRK1 (0.61) | NTRK1NTRK3NTRK2CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110156813-B | Heterocyclic compounds as TRK inhibitors | 北京诺诚健华医药科技有限公司 | 2023-07-25 | — | — | CN | disclosed |