Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913928 | 0.89 | AURKA (0.37) | AURKAKITSMN1; SMN2FGFR4HSD17B10 | |
| SCHEMBL2912187 | 0.88 | RXFP1 (0.41) | AURKAKMT2ARXFP1 | |
| SCHEMBL652354 | 0.87 | AURKA (0.41) | HTTAURKAAHRKITSMN1; SMN2 | |
| SCHEMBL2913924 | 0.86 | KDR (0.36) | AURKAKITFGFR4RXFP1NAMPT | |
| SCHEMBL2911949 | 0.85 | EGLN1 (0.38) | AURKAKITSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2914823 | 0.84 | AURKA (0.35) | AURKAFGFR4RXFP1 | |
| SCHEMBL2914426 | 0.84 | KIT (0.35) | AURKAKITSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2905881 | 0.84 | RXFP1 (0.44) | AURKASMN1; SMN2MEN1KMT2AFGFR4 | |
| SCHEMBL2910927 | 0.82 | GRM4 (0.39) | AURKAMEN1KMT2AFGFR4RXFP1 | |
| SCHEMBL4082256 | 0.81 | AURKA (0.44) | HTTAURKAAHRSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051981-B1 | 1H-FURO[3,2-C] PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-08-25 | — | — | EP | claimed |