Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | BCR | P11274 | 2/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652354 | 0.94 | AURKA (0.41) | AURKAALDH1A1SMN1; SMN2NAMPTNPC1 | |
| SCHEMBL4078238 | 0.87 | AURKA (0.43) | AURKAALDH1A1SMN1; SMN2PHGDHCYP1A2 | |
| SCHEMBL4078547 | 0.87 | AURKA (0.46) | AURKAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4088217 | 0.85 | AURKA (0.51) | AURKAABL1BCRMAPK1HTT | |
| SCHEMBL4088628 | 0.84 | RAB9A (0.43) | ALDH1A1SMN1; SMN2NAMPTNPC1RAB9A | |
| SCHEMBL4086360 | 0.84 | MAPK1 (0.47) | AURKASMN1; SMN2NPC1RAB9APKM | |
| SCHEMBL4089328 | 0.84 | AURKA (0.43) | AURKANAMPTRAB9ATSHRABL1 | |
| SCHEMBL4093240 | 0.83 | AURKA (0.43) | AURKAPHGDHABL1BCRMAPK1 | |
| SCHEMBL4083886 | 0.83 | AURKA (0.44) | AURKASMN1; SMN2NPC1RAB9APKM | |
| SCHEMBL4078785 | 0.82 | AURKA (0.42) | AURKAALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |