Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 12/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 11/20 | 0.60 |
| ▸ | ULK1 | O75385 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 3/20 | 0.57 |
| ▸ | INSR | P06213 | 3/20 | 0.57 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.56 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.56 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL884818 | 1.00 | MET (0.60) | METALKULK1EGFRINSR | |
| SCHEMBL884883 | 0.92 | MET (0.60) | METALKULK1EGFRINSR | |
| SCHEMBL884620 | 0.91 | MET (0.64) | METALKULK1EGFRINSR | |
| SCHEMBL885245 | 0.89 | MET (0.63) | METALKULK1EGFRINSR | |
| SCHEMBL884691 | 0.88 | MET (0.71) | METALKULK1EGFRINSR | |
| SCHEMBL885001 | 0.88 | ALK (0.71) | METALKULK1EGFRINSR | |
| SCHEMBL885950 | 0.87 | MET (0.63) | METALKULK1EGFRINSR | |
| SCHEMBL886479 | 0.86 | ALK (0.62) | METALKULK1EGFRINSR | |
| SCHEMBL884830 | 0.86 | MET (0.64) | METALKULK1EGFRINSR | |
| SCHEMBL2060554 | 0.86 | MET (0.70) | METALKULK1EGFRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |