Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BUB1 | O43683 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3216325 | 0.69 | BUB1 (0.40) | BUB1BCHEESR2MAPK1NR1H2 | |
| SCHEMBL20780061 | 0.68 | BUB1 (0.50) | BUB1BCHEESR2MAPK1NR1H2 | |
| SCHEMBL15829073 | 0.65 | BUB1 (0.47) | BUB1BCHEESR2MAPK1NR1H2 | |
| SCHEMBL31283508 | 0.65 | BUB1 (0.44) | BUB1BCHEESR2MAPK1NR1H2 | |
| SCHEMBL15417736 | 0.64 | HSP90AA1 (0.47) | BUB1BCHEESR2MAPK1NR1H2 | |
| SCHEMBL31630952 | 0.64 | BUB1 (0.46) | BUB1BCHENR1H2HSP90AA1HSP90AB1 | |
| SCHEMBL28276822 | 0.64 | BUB1 (0.46) | BUB1BCHEESR2MAPK1NR1H2 | |
| SCHEMBL30181262 | 0.62 | BUB1 (0.41) | BUB1BCHEMAPK1NR1H2HSP90AA1 | |
| SCHEMBL15615643 | 0.62 | BCHE (0.41) | BUB1BCHENR1H2HSP90AA1HSP90AB1 | |
| SCHEMBL400481 | 0.62 | BCHE (0.41) | BUB1BCHEESR2HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989194-B1 | CYCLIC SULFONES USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2010-08-25 | — | — | EP | disclosed |
| US-20090099207-A1 | Cyclic sulfones useful as BACE inhibitors | RUEEGER HEINRICH | 2009-04-16 | — | — | US | disclosed |
| EP-1989194-A1 | CYCLIC SULFONES USEFUL AS BACE INHIBITORS | Novartis AG (CH) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007093621-A1 | CYCLIC SULFONES USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2007-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099207-A1 | Cyclic sulfones useful as BACE inhibitors | BACE1, BACE2, APP | BUB1 2833/4885BCHE 47/4885ESR2 1340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.