Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD3 | Q9BZ95 | 12/20 | 1.00 |
| ▸ | NSD2 | O96028 | 11/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.77 |
| ▸ | CA1 | P00915 | 1/20 | 0.70 |
| ▸ | CA2 | P00918 | 1/20 | 0.70 |
| ▸ | CA4 | P22748 | 1/20 | 0.70 |
| ▸ | CA9 | Q16790 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29093676 | 0.89 | NSD3 (0.81) | NSD3NSD2LMNASMN1; SMN2CA1 | |
| SCHEMBL10016522 | 0.87 | LMNA (1.00) | NSD3NSD2LMNASMN1; SMN2CA1 | |
| SCHEMBL29093002 | 0.87 | NSD3 (1.00) | NSD3NSD2LMNASMN1; SMN2CA1 | |
| SCHEMBL29093660 | 0.87 | NSD3 (1.00) | NSD3NSD2LMNASMN1; SMN2CA1 | |
| SCHEMBL29093669 | 0.87 | NSD3 (1.00) | NSD3NSD2LMNASMN1; SMN2CA1 | |
| SCHEMBL29093422 | 0.87 | NSD3 (1.00) | NSD3NSD2LMNASMN1; SMN2CA1 | |
| SCHEMBL29093062 | 0.85 | NSD3 (1.00) | NSD3NSD2LMNASMN1; SMN2CA1 | |
| SCHEMBL29093280 | 0.84 | NSD3 (1.00) | NSD3NSD2LMNASMN1; SMN2CA1 | |
| SCHEMBL13170095 | 0.82 | NSD3 (0.72) | NSD3NSD2LMNASMN1; SMN2CA1 | |
| SCHEMBL29092926 | 0.82 | CA1 (0.70) | NSD3NSD2LMNASMN1; SMN2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116942674-A | Use of purine derivatives as NSD2 and NSD3 inhibitors | 普美瑞(苏州)生物科技有限公司 | 2023-10-27 | — | — | CN | disclosed |