Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.89 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | HCAR3 | P49019 | 13/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL504055 | 0.94 | CASP6 (1.00) | CASP6TSHRLMNAHCAR3APEX1 | |
| SCHEMBL29577830 | 0.94 | CASP6 (1.00) | CASP6TSHRLMNAHCAR3APEX1 | |
| Hydrochloric Acid SCHEMBL11110871 | 0.92 | CASP6 (0.96) | CASP6TSHRLMNAHCAR3APEX1 | |
| SCHEMBL10824709 | 0.92 | CASP6 (0.96) | CASP6TSHRLMNAHCAR3APEX1 | |
| Zinc Ion SCHEMBL6523817 | 0.81 | CASP6 (0.70) | CASP6TSHRLMNAHCAR3APEX1 | |
| SCHEMBL11195885 | 0.81 | CASP6 (0.75) | CASP6TSHRLMNAHCAR3APEX1 | |
| Lithium Ion SCHEMBL30584158 | 0.81 | CASP6 (0.69) | CASP6TSHRLMNAHCAR3 | |
| Lithium Ion SCHEMBL10824708 | 0.81 | CASP6 (0.69) | CASP6TSHRLMNAHCAR3 | |
| SCHEMBL1632594 | 0.80 | CASP6 (0.73) | CASP6TSHRLMNAHCAR3 | |
| SCHEMBL27985417 | 0.80 | CASP6 (0.74) | CASP6TSHRLMNAHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116716762-B | Environment-friendly heat-sensitive paper with good durability and preparation method thereof | 柏仁新材料(广州)股份有限公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-116716762-A | Environment-friendly heat-sensitive paper with good durability and preparation method thereof | 柏仁新材料(广州)股份有限公司 | 2023-09-08 | — | — | CN | disclosed |