Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2909181 | 0.91 | ALDH1A1 (0.67) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL2915511 | 0.85 | KDM4E (0.71) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL2895325 | 0.82 | USP2 (0.64) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL2900626 | 0.80 | KMT2A (0.59) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL2901643 | 0.79 | KDM4E (0.59) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL2911429 | 0.79 | KDM4E (0.61) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL2900654 | 0.78 | KDM4E (0.64) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL2894150 | 0.77 | KDM4E (0.65) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL3012410 | 0.76 | KDM4E (0.64) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL2902769 | 0.76 | KDM4E (0.66) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298324-A1 | Prolyl Hydroxylase Inhibitors | SMITH KLINE BEECHAM CORPORATION (US) | 2010-11-25 | — | — | US | disclosed |
| EP-2240178-A1 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009086044-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITH KLINE BEECHAM CORPORATION (US) | 2009-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298324-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN3, EGLN2 | KDM4E 206/4885ALDH1A1 204/4885SMN1; SMN2 4048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.