Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.39 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.39 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | CPN1 | P15169 | 2/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4435420 | 0.85 | CPN1 (0.41) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| SCHEMBL4420168 | 0.80 | — | — | |
| SCHEMBL1691633 | 0.80 | — | — | |
| SCHEMBL1517058 | 0.80 | — | — | |
| SCHEMBL3931499 | 0.77 | — | — | |
| SCHEMBL17315805 | 0.77 | — | — | |
| SCHEMBL17315807 | 0.77 | — | — | |
| SCHEMBL7514018 | 0.77 | — | — | |
| SCHEMBL1994090 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL20898681 | 0.75 | SLC6A1 (0.44) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116768919-B | Substituted aminophenyl furopyridine compound, preparation method, pharmaceutical composition and application thereof | 南开大学 | 2025-04-22 | — | — | CN | disclosed |
| CN-116768902-B | Substituted phenol hydroxyl phenyl pyrrolopyrimidine compound and preparation method and application thereof | 南开大学 | 2024-09-24 | — | — | CN | disclosed |
| CN-116768902-A | Substituted phenol hydroxyl phenyl pyrrolopyrimidine compound and preparation method and application thereof | 南开大学 | 2023-09-19 | — | — | CN | disclosed |
| CN-116768919-A | Substituted aminophenyl furopyridine compound, preparation method, pharmaceutical composition and application thereof | 南开大学 | 2023-09-19 | — | — | CN | disclosed |