Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6902207 | 0.92 | — | — | |
| SCHEMBL2156622 | 0.87 | TDP1 (0.37) | HTT | |
| SCHEMBL10612665 | 0.74 | GAA (0.39) | GAA | |
| SCHEMBL11862121 | 0.73 | HTT (0.37) | HTTGAAPOLBKMT2AMEN1 | |
| SCHEMBL11153958 | 0.72 | GPR84 (0.33) | MAPT | |
| SCHEMBL9466742 | 0.71 | HTT (0.34) | HTTGAAPOLBKMT2AKDM4E | |
| Acetic Acid SCHEMBL16713425 | 0.68 | GAA (0.38) | HTTGAAPOLBKMT2ARECQL | |
| SCHEMBL14695653 | 0.68 | TDP1 (0.35) | TSHR | |
| SCHEMBL1311884 | 0.68 | TDP1 (0.37) | HTTGAAPOLB | |
| SCHEMBL12646464 | 0.68 | TSHR (0.33) | HTTGAAPOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1964189-B1 | COLOR TUNABLE LIGHT-EMITTING DEVICES AND METHOD OF MAKING THE SAME | GEN ELECTRIC (US) | 2010-08-18 | — | — | EP | disclosed |
| EP-1964189-A1 | COLOR TUNABLE LIGHT-EMITTING DEVICES AND METHOD OF MAKING THE SAME | General Electric Company (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007070162-A1 | COLOR TUNABLE LIGHT-EMITTING DEVICES AND METHOD OF MAKING THE SAME | GENERAL ELECTRIC COMPANY (US) | 2007-06-21 | — | — | WO | disclosed |
| US-20070131949-A1 | Color tunable light-emitting devices and method of making the same | GENERAL ELECTRIC COMPANY (US) | 2007-06-14 | — | — | US | disclosed |
| US-20070132371-A1 | Color tunable light-emitting devices and method of making the same | GENERAL ELECTRIC COMPANY (US) | 2007-06-14 | — | — | US | disclosed |
| US-5431697-A | Reversibly variable color patterning composition for synthetic resin articles | MATSUI SHIKISO CHEMICAL CO., LTD. (JP) | 1995-07-11 | — | — | US | disclosed |
| US-5221288-A | Treating cellulose fiber textile product with cationic compound, immersing in dispersion of microencapsulated thermochromic or photochromic material | MATSUI SHIKISO CHEMICAL CO., LTD. (JP) | 1993-06-22 | — | — | US | disclosed |
| EP-0480162-A1 | Dyeing method and dyed product | MATSUI SHIKISO CHEMICAL CO., LTD (JP) | 1992-04-15 | — | — | EP | disclosed |