SCHEMBL29095907

SCHEMBL29095907

C=C(C)C(C)(O)C#Cc1ccccc1Cl

nearest known ligand 0.40

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.40
GRM5 P41594 2/20 0.37
PTGDR2 Q9Y5Y4 5/20 0.35
FFAR1 O14842 1/20 0.33
CNR1 P21554 1/20 0.33
CNR2 P34972 1/20 0.33
PGK1 P00558 1/20 0.31
MAPT P10636 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C19 P33261 1/20 0.31
BLM P54132 1/20 0.30
HSD11B1 P28845 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11444986 0.84 KCNH2 (0.46) KCNH2GRM5PTGDR2FFAR1CNR1
SCHEMBL1921804 0.76 KCNH2 (0.48) KCNH2GRM5PTGDR2FFAR1CNR1
SCHEMBL29116864 0.75 MAPT (0.53) KCNH2MAPTBLM
SCHEMBL29096084 0.72 MAPT (0.43) KCNH2GRM5MAPT
SCHEMBL29096090 0.71 KCNH2 (0.44) KCNH2GRM5PTGDR2MAPTCYP3A4
SCHEMBL30597666 0.71 KCNH2 (0.44) KCNH2GRM5PTGDR2MAPTCYP3A4
SCHEMBL27343866 0.69 KCNH2 (0.48) KCNH2GRM5PTGDR2FFAR1CYP3A4
SCHEMBL4448140 0.69 KCNH2 (0.61) KCNH2GRM5PTGDR2FFAR1
SCHEMBL30707788 0.69 KCNH2 (0.61) KCNH2GRM5PTGDR2FFAR1
SCHEMBL12430909 0.66 PTGDR2 (0.46) KCNH2GRM5PTGDR2FFAR1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116969819-A Method for realizing visible light-induced intramolecular alkynyl migration of 1, 4-eneyne compound and realizing unactivated olefin difunctional 哈尔滨工业大学 2023-10-31 CN disclosed