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SCHEMBL2909672

SCHEMBL2909672

CCOC(=O)c1cnc2cc(OCC)c(N3CCN(C)CC3)cc2c1Nc1cccc(Cl)c1F

nearest known ligand 0.71

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ KCNH2 Q12809 6/20 0.71
▸ SCN5A Q14524 3/20 0.71
▸ CSF1R P07333 12/20 0.62
▸ MEN1 O00255 3/20 0.49
▸ KMT2A Q03164 3/20 0.49
▸ GAA P10253 1/20 0.49
▸ SLC2A1 P11166 1/20 0.49
▸ MAPK10 P53779 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2912249 0.95 KCNH2 (0.64) KCNH2SCN5ACSF1RMEN1KMT2A
SCHEMBL2911912 0.93 KCNH2 (0.62) KCNH2SCN5ACSF1RMEN1KMT2A
SCHEMBL2912403 0.93 KCNH2 (0.61) KCNH2SCN5ACSF1R
SCHEMBL2910961 0.93 KCNH2 (0.67) KCNH2SCN5ACSF1RMEN1KMT2A
SCHEMBL2942850 0.93 KCNH2 (0.61) KCNH2SCN5ACSF1RMEN1KMT2A
SCHEMBL2910808 0.92 KCNH2 (0.60) KCNH2SCN5ACSF1RMEN1KMT2A
SCHEMBL2912423 0.92 KCNH2 (0.84) KCNH2SCN5ACSF1RMEN1KMT2A
SCHEMBL2910208 0.92 KCNH2 (0.73) KCNH2SCN5ACSF1RMEN1KMT2A
SCHEMBL2913688 0.92 KCNH2 (0.60) KCNH2SCN5ACSF1RGAA
SCHEMBL2907118 0.92 CSF1R (0.68) KCNH2SCN5ACSF1RMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2010496-B1 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS ASTRAZENECA AB (SE) 2010-08-25 — — EP disclosed