Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.60 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.60 |
| ▸ | CSF1R | P07333 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910268 | 0.92 | KCNH2 (0.70) | KCNH2SCN5ACSF1RMAPTGAA | |
| SCHEMBL2910088 | 0.92 | KCNH2 (0.61) | KCNH2SCN5ACSF1RMAPTCA2 | |
| SCHEMBL2910958 | 0.92 | KCNH2 (0.72) | KCNH2SCN5ACSF1R | |
| SCHEMBL2909672 | 0.92 | KCNH2 (0.71) | KCNH2SCN5ACSF1RGAA | |
| SCHEMBL2912403 | 0.91 | KCNH2 (0.61) | KCNH2SCN5ACSF1RMAPT | |
| SCHEMBL2910808 | 0.90 | KCNH2 (0.60) | KCNH2SCN5ACSF1RMAPTGAA | |
| SCHEMBL2913777 | 0.88 | KCNH2 (0.58) | KCNH2SCN5ACSF1RMAPTCA2 | |
| SCHEMBL2942850 | 0.87 | KCNH2 (0.61) | KCNH2SCN5ACSF1RCA2GAA | |
| SCHEMBL2914058 | 0.87 | KCNH2 (0.63) | KCNH2SCN5ACSF1RMAPTGAA | |
| SCHEMBL2911172 | 0.87 | MAPT (0.52) | KCNH2SCN5ACSF1RMAPTCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |