Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.36 |
| ▸ | FEN1 | P39748 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 4/20 | 0.35 |
| ▸ | GSK3A | P49840 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 2/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2906814 | 1.00 | ALOX5AP (0.36) | ALOX5APFEN1GSK3BGSK3AALDH1A1 | |
| SCHEMBL2912215 | 0.93 | GSK3B (0.42) | ALOX5APFEN1GSK3BGSK3AALDH1A1 | |
| SCHEMBL2905628 | 0.93 | ALOX5AP (0.35) | ALOX5APFEN1GSK3BGSK3AALDH1A1 | |
| SCHEMBL2905208 | 0.93 | GSK3B (0.42) | ALOX5APFEN1GSK3BGSK3AALDH1A1 | |
| SCHEMBL2913460 | 0.93 | GSK3B (0.40) | ALOX5APFEN1GSK3BGSK3AALDH1A1 | |
| SCHEMBL2944754 | 0.93 | ALOX5AP (0.35) | ALOX5APFEN1GSK3BGSK3AALDH1A1 | |
| SCHEMBL2907240 | 0.93 | GSK3B (0.40) | ALOX5APFEN1GSK3BGSK3AALDH1A1 | |
| SCHEMBL2912014 | 0.92 | ALOX5AP (0.43) | ALOX5APFEN1GSK3BGSK3AALDH1A1 | |
| SCHEMBL2904400 | 0.92 | ALOX5AP (0.43) | ALOX5APFEN1GSK3BGSK3AALDH1A1 | |
| SCHEMBL2904127 | 0.91 | MET (0.35) | ALOX5APFEN1GSK3BGSK3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |