SCHEMBL29101210

SCHEMBL29101210

O=[N+]([O-])C1=CC=C(C2=CCNCC2)CN1

nearest known ligand 0.40

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 4/20 0.39
HTR2A P28223 1/20 0.39
SIGMAR1 Q99720 2/20 0.38
HTR2C P28335 4/20 0.37
QDPR P09417 2/20 0.36
HRH3 Q9Y5N1 1/20 0.33
KHK P50053 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4789631 0.68 HTR2C (0.56) HTR6HTR2ASIGMAR1HTR2CQDPR
Hydrochloric Acid SCHEMBL9958496 0.67 HTR2C (0.57) HTR6HTR2ASIGMAR1HTR2CQDPR
SCHEMBL29029335 0.67 CCNT1 (0.41) SIGMAR1HTR2CQDPR
Hydrochloric Acid SCHEMBL29266476 0.66 CCNT1 (0.40) SIGMAR1HTR2CQDPR
SCHEMBL1671185 0.65
SCHEMBL15077316 0.65 HTR6 (0.51) HTR6HTR2ASIGMAR1HTR2CQDPR
Hydrochloric Acid SCHEMBL1513499 0.65 HTR2C (0.53) HTR6HTR2ASIGMAR1HTR2CQDPR
SCHEMBL4790049 0.65 HTR2C (0.53) HTR6HTR2ASIGMAR1HTR2CQDPR
SCHEMBL15770800 0.64 HTR2C (0.41) HTR6HTR2ASIGMAR1HTR2CHRH3
SCHEMBL4789895 0.63 HTR2C (0.57) HTR6HTR2ASIGMAR1HTR2CQDPR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116940563-A CDK inhibitors and their use as pharmaceuticals 普莱鲁德疗法有限公司 2023-10-24 CN disclosed
CN-116583283-A CDK inhibitors and their use as pharmaceuticals 普莱鲁德疗法有限公司 2023-08-11 CN disclosed