Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.65 |
| ▸ | RAB9A | P51151 | 7/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2348306 | 0.86 | RAB9A (0.58) | NPC1RAB9ASMN1; SMN2EPHX2TSHR | |
| SCHEMBL2911825 | 0.83 | MAPK14 (0.71) | SMN1; SMN2ALDH1A1MAPK14 | |
| SCHEMBL2342855 | 0.83 | MAPK14 (0.71) | SMN1; SMN2ALDH1A1MAPK14 | |
| SCHEMBL2912814 | 0.82 | MAPK14 (0.71) | NPC1RAB9AHTTALDH1A1MAPK14 | |
| SCHEMBL2907491 | 0.81 | EPHX2 (0.57) | NPC1RAB9ASMN1; SMN2EPHX2EPHX1 | |
| SCHEMBL2907245 | 0.81 | MAPK14 (0.68) | NPC1RAB9ASMN1; SMN2EPHX2MAPK14 | |
| SCHEMBL18735757 | 0.80 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2EPHX2TSHR | |
| SCHEMBL2915194 | 0.80 | MAPK14 (0.71) | NPC1RAB9AHTTMAPK14 | |
| SCHEMBL2349750 | 0.79 | MAPK14 (0.69) | EPHX2MAPK14 | |
| SCHEMBL2912684 | 0.79 | MAPK14 (0.69) | NPC1RAB9ASMN1; SMN2EPHX2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940786-B1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LTD (GB) | 2010-08-18 | — | — | EP | disclosed |
| US-20080255105-A1 | Biphenyl Derivatives and Their Use in Treating Hepatitis C | ARROW THERAPEUTICS LIMITED (GB) | 2008-10-16 | — | — | US | disclosed |
| EP-1940786-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007031791-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255105-A1 | Biphenyl Derivatives and Their Use in Treating Hepatitis C | NR4A1, NR0B1, NR1H4 | NPC1 146/4885RAB9A 1870/4885SMN1; SMN2 2314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.