SCHEMBL29101804

SCHEMBL29101804

Cc1ccc(-c2nc3cc(C)c(C)cc3[nH]c2=O)cc1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.66
KDM4E B2RXH2 4/20 0.66
MAPK8 P45983 1/20 0.48
MAPK9 P45984 1/20 0.48
MAPK10 P53779 1/20 0.48
NPC1 O15118 3/20 0.47
ATM Q13315 3/20 0.46
ERAP1 Q9NZ08 1/20 0.46
FABP6 P51161 1/20 0.45
HPSE Q9Y251 1/20 0.45
GRIN2D O15399 1/20 0.44
GRIN3B O60391 1/20 0.44
GRIN1 Q05586 1/20 0.44
GRIN2A Q12879 1/20 0.44
GRIN2B Q13224 1/20 0.44
GRIN2C Q14957 1/20 0.44
GRIN3A Q8TCU5 1/20 0.44
PDGFRB P09619 1/20 0.44
FGFR1 P11362 1/20 0.44
KDR P35968 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29101810 0.88 RAB9A (0.64) RAB9AKDM4EMAPK8MAPK9MAPK10
SCHEMBL31448344 0.79 KDM4E (1.00) RAB9AKDM4ENPC1STK33MEN1
SCHEMBL28362353 0.79 KDM4E (1.00) RAB9AKDM4ENPC1STK33MEN1
SCHEMBL18000032 0.78 KDM4E (0.54) RAB9AKDM4ENPC1
SCHEMBL25722414 0.77 HPSE (0.64) RAB9ANPC1HPSEMEN1MAPT
SCHEMBL2630604 0.75 RAB9A (0.74) RAB9AKDM4ENPC1GRIN2DGRIN3B
SCHEMBL11370785 0.74 GRIN2D (0.56) RAB9AKDM4ENPC1ATMERAP1
SCHEMBL28081555 0.74 RAB9A (0.68) RAB9AKDM4EMAPK8MAPK9MAPK10
Lumichrome SCHEMBL974856 0.73 ATM (0.50) RAB9AKDM4EMAPK8MAPK9MAPK10
Lumichrome SCHEMBL30432151 0.73 ATM (0.50) RAB9AKDM4EMAPK8MAPK9MAPK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116987039-A Synthesis method of 3-substituted quinoxaline-2 (1H) -ketone derivative 福建医科大学 2023-11-03 CN disclosed