Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCDIN3D | Q7Z5W3 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 6/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.47 |
| ▸ | CDK1 | P06493 | 4/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.47 |
| ▸ | CDK4 | P11802 | 4/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.47 |
| ▸ | CCND1 | P24385 | 2/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.46 |
| ▸ | CLK1 | P49759 | 12/20 | 0.41 |
| ▸ | CLK2 | P49760 | 12/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 12/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 3/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913424 | 0.87 | CDK2 (0.47) | CDK2CCNA2CDK1CCNB1CDK4 | |
| SCHEMBL2937905 | 0.86 | CLK1 (0.48) | CDK2CCNA2CDK1CCNB1CDK4 | |
| SCHEMBL2905018 | 0.86 | CDK2 (0.64) | BCDIN3DCDK2CCNA2CDK1CCNB1 | |
| SCHEMBL2911054 | 0.86 | CDK2 (0.46) | BCDIN3DCDK2CCNA2CDK1CCNB1 | |
| SCHEMBL2912355 | 0.84 | CDK2 (0.48) | BCDIN3DCDK2CCNA2CDK1CCNB1 | |
| SCHEMBL2912755 | 0.84 | CDK2 (0.50) | CDK2CCNA2CDK1CCNB1CDK4 | |
| SCHEMBL2907796 | 0.82 | CLK1 (0.43) | BCDIN3DCDK2CCNA2CDK1CCNB1 | |
| SCHEMBL3445887 | 0.82 | CDK2 (0.53) | BCDIN3DCDK2CCNA2CDK1CCNB1 | |
| SCHEMBL2907818 | 0.82 | CDK2 (0.49) | BCDIN3DCDK2CCNA2CDK1CCNB1 | |
| SCHEMBL2905169 | 0.81 | BCDIN3D (0.45) | BCDIN3DCDK2CCNA2CDK5CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1348707-B1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | USTAV EX BOTAN AV CR V V I I O (CZ) | 2010-08-25 | — | — | EP | disclosed |
| US-7745450-B2 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | INSTITUTE OF EXPERIMENTAL BOTANY (CZ) | 2010-06-29 | — | — | US | disclosed |
| US-20050080097-A1 | Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy | USTAV EXPERIMENTALNI BOTANIKY AV CR (INSTITUTE OF EXPERIMENTAL BOTANY ACADEMY OF | 2005-04-14 | — | — | US | disclosed |
| EP-1348707-A1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | Ustav Experimentalni Botaniky AV CR (Institute of Experimental Botany Academy of Sciences of the Czech Republic) (CZ) | 2003-10-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080097-A1 | Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy | CBR3, DHFR, AKR1C3 | BCDIN3D 1217/4885CDK2 685/4885CCNA2 767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.