Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | TDO2 | P48775 | 2/20 | 0.46 |
| ▸ | CASP6 | P55212 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251800 | 0.89 | PDE10A (0.56) | ALDH1A1MAPTMAPK1PDE10AL3MBTL1 | |
| SCHEMBL29508937 | 0.89 | PDE10A (0.56) | ALDH1A1MAPTMAPK1PDE10AL3MBTL1 | |
| Formic Acid Methyl Ester SCHEMBL29210524 | 0.81 | ALDH1A1 (0.48) | ALDH1A1MAPTMAPK1PDE10AL3MBTL1 | |
| Alcohol SCHEMBL27548373 | 0.76 | HSD17B10 (0.58) | ALDH1A1L3MBTL1MEN1KMT2ALMNA | |
| Alcohol SCHEMBL28728870 | 0.75 | TDP1 (0.50) | ALDH1A1MEN1KMT2ALMNATDP1 | |
| SCHEMBL30425516 | 0.74 | PDE10A (0.51) | ALDH1A1MAPTMAPK1PDE10AL3MBTL1 | |
| SCHEMBL9986678 | 0.74 | PDE10A (0.51) | ALDH1A1MAPTMAPK1PDE10AL3MBTL1 | |
| SCHEMBL3769047 | 0.74 | PDE10A (0.51) | ALDH1A1MAPTPDE10AL3MBTL1POLB | |
| SCHEMBL13748713 | 0.73 | NAPRT (0.51) | ALDH1A1PDE10AKMT2AKDM4ENPC1 | |
| SCHEMBL9640945 | 0.73 | ALDH1A1 (0.50) | ALDH1A1MAPTMAPK1PDE10AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117024334-A | Synthesis method of 2-fluoro-3-hydroxypyridine | 重庆医药高等专科学校 | 2023-11-10 | — | — | CN | claimed |
| CN-117024334-A | Synthesis method of 2-fluoro-3-hydroxypyridine | 重庆医药高等专科学校 | 2023-11-10 | — | — | CN | disclosed |