Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 14/20 | 0.75 |
| ▸ | CDK1 | P06493 | 13/20 | 0.75 |
| ▸ | CCND1 | P24385 | 12/20 | 0.75 |
| ▸ | CDK9 | P50750 | 11/20 | 0.75 |
| ▸ | CDK2 | P24941 | 11/20 | 0.75 |
| ▸ | CCNB1 | P14635 | 10/20 | 0.75 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.75 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.75 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.75 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.75 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.75 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.75 |
| ▸ | CCND3 | P30281 | 4/20 | 0.75 |
| ▸ | GSK3A | P49840 | 4/20 | 0.75 |
| ▸ | CDK7 | P50613 | 3/20 | 0.75 |
| ▸ | CCNH | P51946 | 2/20 | 0.75 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.75 |
| ▸ | MAPK15 | Q8TD08 | 2/20 | 0.75 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.75 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6524830 | 1.00 | CDK4 (0.75) | CDK4CDK1CCND1CDK9CDK2 | |
| SCHEMBL291053 | 1.00 | CDK4 (0.75) | CDK4CDK1CCND1CDK9CDK2 | |
| SCHEMBL291051 | 1.00 | CDK4 (0.75) | CDK4CDK1CCND1CDK9CDK2 | |
| Hydrochloric Acid SCHEMBL3108717 | 0.99 | CDK4 (0.75) | CDK4CDK1CCND1CDK9CDK2 | |
| Hydrochloric Acid SCHEMBL3108722 | 0.99 | CDK4 (0.75) | CDK4CDK1CCND1CDK9CDK2 | |
| Hydrochloric Acid SCHEMBL3108728 | 0.99 | CDK4 (0.75) | CDK4CDK1CCND1CDK9CDK2 | |
| Acetic Acid SCHEMBL3105601 | 0.97 | CDK4 (0.71) | CDK4CDK1CCND1CDK9CDK2 | |
| Acetic Acid SCHEMBL3105617 | 0.97 | CDK4 (0.71) | CDK4CDK1CCND1CDK9CDK2 | |
| Nitric Acid SCHEMBL3104675 | 0.95 | CDK4 (0.69) | CDK4CDK1CCND1CDK9CDK2 | |
| Nitric Acid SCHEMBL3104690 | 0.95 | CDK4 (0.69) | CDK4CDK1CCND1CDK9CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130045993-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES AND THEIR USE | Piramal Enterprises Limited (IN) | 2013-02-21 | — | — | US | claimed |
| US-8304449-B2 | Inhibitors of cyclin dependent kinases and their use | PIRAMAL HEALTHCARE LIMITED (IN) | 2012-11-06 | — | — | US | claimed |
| US-20110136873-A1 | Inhibitors of Cyclin Dependent Kinases and Their Use | PIRAMAL LIFE SCIENCES LTD. (IN) | 2011-06-09 | — | — | US | claimed |
| US-7915301-B2 | chromenone derivatives of nitrogen-, oxygen- or sulfur-containing saturated heterocycles; preparation by cyclizing benzoyl intermediates; antiproliferative agents; 2-(2-Chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one | Piramal Life Science Limited (IN) | 2011-03-29 | — | — | US | claimed |
| US-7884127-B2 | chromenone derivatives of nitrogen-, oxygen- or sulfur-containing saturated heterocycles; preparation by cyclizing benzoyl intermediates; antiproliferative agents; 2-(2-Chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one; acidification | Pirimal Life Sciences Ltd. (IN) | 2011-02-08 | — | — | US | claimed |
| US-20100179210-A1 | NOVEL ENANTIOMERICALLY PURE COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Piramal Enterprises Limited (IN) | 2010-07-15 | — | — | US | claimed |
| EP-2046738-A1 | ENANTIOMERICALLY PURE FLAVONE DERIVATIVES FOR THE TREATMENT OF POLIFERATIVE DISORDERS AND PROCESSES FOR THEIR PREPARATION | Piramal Life Sciences Limited (IN) | 2009-04-15 | — | — | EP | claimed |
| EP-1556375-B1 | FLAVONE DERIVATIVES AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | NICHOLAS PIRAMAL INDIA LTD (IN) | 2008-06-25 | — | — | EP | claimed |
| US-20080108690-A1 | INHIBITORS OF CYCLIN DEPENDENT KINASES AND THEIR USE | NICHOLAS PIRAMAL INDIA LIMITED (IN) | 2008-05-08 | — | — | US | claimed |
| WO-2007148158-A1 | ENANTIOMERICALLY PURE FLAVONE DERIVATIVES FOR THE TREATMENT OF POLIFERATIVE DISORDERS AND PROCESSES FOR THEIR PREPARATION | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2007-12-27 | — | — | WO | claimed |
| US-7271193-B2 | Inhibitors of cyclin-dependent kinases and their use | NICHOLAS PIRAMAL INDIA, LTD. (IN) | 2007-09-18 | — | — | US | claimed |
| US-20070015802-A1 | chromenone derivatives of nitrogen-, oxygen- or sulfur-containing saturated heterocycles; preparation by cyclizing benzoyl intermediates; antiproliferative agents; 2-(2-Chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one; acidification | NICHOLAS PIRAMAL INDIA LIMITED (IN) | 2007-01-18 | — | — | US | claimed |
| US-20040106581-A1 | Inhibitors of cyclin-dependent kinases and their use | NICHOLAS PIRAMAL INDIA LIMITED (IN) | 2004-06-03 | — | — | US | claimed |
| US-12383530-B2 | Pharmaceutical combination for the treatment of melanoma | Piramal Enterprises Limited (IN) | 2025-08-12 | — | — | US | disclosed |
| US-20250195467-A1 | COMPOUNDS FOR THE TREATMENT OF CANCERS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS | Piramal Enterprises Limited (IN) | 2025-06-19 | — | — | US | disclosed |
| US-12076309-B2 | Compounds for the treatment of cancers associated with human papillomavirus | Piramal Enterprises Limited (IN) | 2024-09-03 | — | — | US | disclosed |
| US-20070015802-A1 | chromenone derivatives of nitrogen-, oxygen- or sulfur-containing saturated heterocycles; preparation by cyclizing benzoyl intermediates; antiproliferative agents; 2-(2-Chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one; acidification | NICHOLAS PIRAMAL INDIA LIMITED (IN) | 2007-01-18 | — | — | US | disclosed |
| EP-1556375-A2 | FLAVONE DERIVATIVES AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | Nicholas Piramal India Limited (IN) | 2005-07-27 | — | — | EP | disclosed |
| US-20040106581-A1 | Inhibitors of cyclin-dependent kinases and their use | NICHOLAS PIRAMAL INDIA LIMITED (IN) | 2004-06-03 | — | — | US | disclosed |
| WO-2004004632-A2 | FLAVONE DERIVATIVES AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | NICHOLAS PIRAMAL INDIA LIMITED (IN) | 2004-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12383530-B2 | Pharmaceutical combination for the treatment of melanoma | BRAF, CCNI, CDK1 | CDK4 4/4885CDK1 3/4885CCND1 55/4885 |
| US-20100179210-A1 | NOVEL ENANTIOMERICALLY PURE COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | CDK2, CDK9, CDK1 | CDK4 5/4885CDK1 3/4885CCND1 21/4885 |
| US-20040106581-A1 | Inhibitors of cyclin-dependent kinases and their use | CCNK, CCNI, CDK1 | CDK4 8/4885CDK1 3/4885CCND1 27/4885 |
| US-20080108690-A1 | INHIBITORS OF CYCLIN DEPENDENT KINASES AND THEIR USE | CDK1, CCNK, CCNI | CDK4 11/4885CDK1 1/4885CCND1 22/4885 |
| US-12076309-B2 | Compounds for the treatment of cancers associated with human papillomavirus | TP53, VHL, POLI | CDK4 19/4885CDK1 139/4885CCND1 131/4885 |
| US-20110136873-A1 | Inhibitors of Cyclin Dependent Kinases and Their Use | CDK1, CCNK, CCNI | CDK4 11/4885CDK1 1/4885CCND1 22/4885 |
| US-20250195467-A1 | COMPOUNDS FOR THE TREATMENT OF CANCERS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS | TP53, VHL, POLI | CDK4 19/4885CDK1 139/4885CCND1 131/4885 |
| US-20130045993-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES AND THEIR USE | CDK1, CCNK, CCNI | CDK4 7/4885CDK1 1/4885CCND1 16/4885 |
| US-20070015802-A1 | chromenone derivatives of nitrogen-, oxygen- or sulfur-containing saturated heterocycles; preparation by cyclizing benzoyl intermediates; antiproliferative agents; 2-(2-Chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one; acidification | CCNI, CDK1, CCNA1 | CDK4 7/4885CDK1 2/4885CCND1 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.