Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13329219 | 0.88 | ALDH1A1 (0.72) | ALDH1A1HTTKMT2AMEN1GLA | |
| SCHEMBL29799018 | 0.84 | KMT2A (0.61) | ALDH1A1HTTKMT2AMEN1GLA | |
| SCHEMBL8471830 | 0.84 | KMT2A (0.61) | ALDH1A1HTTKMT2AMEN1GLA | |
| SCHEMBL11822208 | 0.84 | ALDH1A1 (0.61) | ALDH1A1HTTKMT2AMEN1GLA | |
| SCHEMBL31184166 | 0.84 | ALDH1A1 (0.61) | ALDH1A1HTTKMT2AMEN1GLA | |
| SCHEMBL11100290 | 0.81 | KMT2A (0.44) | ALDH1A1HTTKMT2AMEN1GLA | |
| SCHEMBL19734857 | 0.78 | ALDH1A1 (0.55) | ALDH1A1HTTKMT2AMEN1GLA | |
| SCHEMBL2561930 | 0.78 | KMT2A (0.50) | ALDH1A1HTTKMT2AMEN1GLA | |
| SCHEMBL2911376 | 0.78 | KMT2A (0.64) | ALDH1A1HTTKMT2AMEN1GLA | |
| SCHEMBL2905211 | 0.78 | ALDH1A1 (0.50) | ALDH1A1HTTKMT2AMEN1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113929622-B | Synthesis method of 2,5, 6-trichloro-cyanogen | 山西永津集团有限公司 | 2023-11-10 | — | — | CN | claimed |
| CN-113929622-A | Synthetic method of 2,5, 6-trichloro-cyanic acid | 山西永津集团有限公司 | 2022-01-14 | — | — | CN | claimed |
| CN-113929622-B | Synthesis method of 2,5, 6-trichloro-cyanogen | 山西永津集团有限公司 | 2023-11-10 | — | — | CN | disclosed |
| CN-113929622-B | Synthesis method of 2,5, 6-trichloro-cyanogen | 山西永津集团有限公司 | 2023-11-10 | — | — | CN | disclosed |
| CN-113929622-A | Synthetic method of 2,5, 6-trichloro-cyanic acid | 山西永津集团有限公司 | 2022-01-14 | — | — | CN | disclosed |
| CN-113929622-A | Synthetic method of 2,5, 6-trichloro-cyanic acid | 山西永津集团有限公司 | 2022-01-14 | — | — | CN | disclosed |
| US-10342782-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2019-07-09 | — | — | US | disclosed |
| US-10342782-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2019-07-09 | — | — | US | disclosed |
| US-20180028501-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2018-02-01 | — | — | US | disclosed |
| US-20180028501-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2018-02-01 | — | — | US | disclosed |
| US-20180028501-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2018-02-01 | — | — | US | disclosed |
| US-8071776-B2 | Thienopyridines as allosteric potentiators of the M4 muscarinic receptor | ELI LILLY AND COMPANY (US) | 2011-12-06 | — | — | US | disclosed |
| US-8071776-B2 | Thienopyridines as allosteric potentiators of the M4 muscarinic receptor | ELI LILLY AND COMPANY (US) | 2011-12-06 | — | — | US | disclosed |
| US-8071776-B2 | Thienopyridines as allosteric potentiators of the M4 muscarinic receptor | ELI LILLY AND COMPANY (US) | 2011-12-06 | — | — | US | disclosed |
| EP-1807434-B1 | THIENOPYRIDINES AS ALLOSTERIC POTENTIATORS OF THE M4 MUSCARINIC RECEPTOR | LILLY CO ELI (US) | 2010-08-25 | — | — | EP | disclosed |
| US-20090105244-A1 | THIENOPYRIDINES AS ALLOSTERIC POTENTIATORS OF THE M4 MUSCARINIC RECEPTOR | ELI LILLY AND COMPANY (US) | 2009-04-23 | — | — | US | disclosed |
| US-20090105244-A1 | THIENOPYRIDINES AS ALLOSTERIC POTENTIATORS OF THE M4 MUSCARINIC RECEPTOR | ELI LILLY AND COMPANY (US) | 2009-04-23 | — | — | US | disclosed |
| US-20090105244-A1 | THIENOPYRIDINES AS ALLOSTERIC POTENTIATORS OF THE M4 MUSCARINIC RECEPTOR | ELI LILLY AND COMPANY (US) | 2009-04-23 | — | — | US | disclosed |
| EP-1807434-A1 | THIENOPYRIDINES AS ALLOSTERIC POTENTIATORS OF THE M4 MUSCARINIC RECEPTOR | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006047124-A1 | THIENOPYRIDINES AS ALLOSTERIC POTENTIATORS OF THE M4 MUSCARINIC RECEPTOR | ELI LILLY AND COMPANY (US) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105244-A1 | THIENOPYRIDINES AS ALLOSTERIC POTENTIATORS OF THE M4 MUSCARINIC RECEPTOR | CHRM2, CHRM4, CHRM1 | ALDH1A1 2594/4885HTT 2251/4885KMT2A 3096/4885 |
| US-10342782-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | CHRM4, CHRM2, CHRM1 | ALDH1A1 3342/4885HTT 1807/4885KMT2A 932/4885 |
| US-20180028501-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM2, CHRM1 | ALDH1A1 3342/4885HTT 1807/4885KMT2A 932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.