Methane

Methane

SCHEMBL29109682

C.O=C(O)c1cccc(-c2ccccc2-c2ccccc2)c1

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMO O15229 2/20 0.68
PTGER1 P34995 3/20 0.59
RXRA P19793 1/20 0.55
RXRB P28702 1/20 0.55
FOLH1 Q04609 3/20 0.54
NR1H4 Q96RI1 2/20 0.54
FNTA P49354 1/20 0.54
FNTB P49356 1/20 0.54
DDT P30046 1/20 0.53
HDAC8 Q9BY41 1/20 0.52
KEAP1 Q14145 1/20 0.51
CYP2C9 P11712 1/20 0.51
DAO P14920 1/20 0.50
TSHR P16473 1/20 0.50
NAPRT Q6XQN6 1/20 0.50
PDK2 Q15119 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL382724 0.98 KMO (0.70) KMOPTGER1RXRARXRBFOLH1
SCHEMBL11498188 0.96 KMO (0.68) KMOPTGER1RXRARXRBFOLH1
SCHEMBL30259065 0.96 KMO (0.73) KMOPTGER1RXRARXRBFOLH1
SCHEMBL2213546 0.96 KMO (0.73) KMOPTGER1RXRARXRBFOLH1
SCHEMBL1707626 0.94 KMO (0.70) KMOPTGER1RXRARXRBFOLH1
SCHEMBL3809549 0.89 KMO (0.63) KMOPTGER1RXRARXRBFOLH1
SCHEMBL8590608 0.88 KMO (0.58) KMOPTGER1RXRARXRBFOLH1
SCHEMBL10029708 0.86 ATM (0.61) KMOPTGER1HDAC8
SCHEMBL16749639 0.85 KMO (0.69) KMORXRARXRBFOLH1DDT
SCHEMBL29386545 0.85 KMO (0.69) KMORXRARXRBFOLH1DDT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113957094-B Delivery system with enhanced gene editing efficiency, preparation method and application 华中科技大学同济医学院附属协和医院 2023-11-21 CN claimed
CN-113957094-B Delivery system with enhanced gene editing efficiency, preparation method and application 华中科技大学同济医学院附属协和医院 2023-11-21 CN disclosed