Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911008 | 1.00 | PRMT5 (0.38) | PRMT5WDR77KCNJ1CTSBPTGDR2 | |
| SCHEMBL28688584 | 0.80 | MAPT (0.42) | PTGDR2CYP1A2ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL2021778 | 0.79 | PRMT5 (0.48) | PRMT5WDR77CTSBCYP1A2ALDH1A1 | |
| SCHEMBL2021776 | 0.79 | PRMT5 (0.48) | PRMT5WDR77CTSBCYP1A2ALDH1A1 | |
| SCHEMBL31374520 | 0.77 | ALDH1A1 (0.40) | PTGDR2CYP1A2ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL8586072 | 0.77 | KDM4E (0.37) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL32662599 | 0.77 | CYP1A2 (0.46) | PTGDR2CYP1A2ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL2916438 | 0.76 | HSP90AA1 (0.40) | KCNJ1PTGDR2CYP1A2ALDH1A1NPSR1 | |
| SCHEMBL2916434 | 0.76 | HSP90AA1 (0.40) | KCNJ1PTGDR2CYP1A2ALDH1A1NPSR1 | |
| SCHEMBL28102381 | 0.76 | ALDH1A1 (0.46) | PTGDR2CYP1A2ALDH1A1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1637528-B1 | Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease | VERTEX PHARMA (US) | 2010-09-01 | — | — | EP | disclosed |
| EP-1637528-A1 | Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease | Vertex Pharmaceuticals Incorporated (US) | 2006-03-22 | — | — | EP | disclosed |
| CN-1110491-C | Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease | VERTEX PHARMA (US) | 2003-06-04 | — | — | CN | disclosed |
| EP-0833826-B1 | Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease | VERTEX PHARMA (US) | 2002-01-23 | — | — | EP | disclosed |
| EP-1136479-A1 | Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease | Vertex Pharmaceuticals Incorporated (US) | 2001-09-26 | — | — | EP | disclosed |
| US-6127372-A | FOR TREATMENT OR PREVENTION OF VIRAL DISEASES, ESPECIALLY AIDS OR HIV | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 2000-10-03 | — | — | US | disclosed |
| US-5990155-A | VIRICIDES AGAINST THE HIV-1 AND HIV-2 VIRUSES; REVERSE TRANSCRIPTASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0749421-B1 | SULPHONAMIDE DERIVATIVES AS ASPARTYL PROTEASE INHIBITORS | VERTEX PHARMA (US) | 1999-09-15 | — | — | EP | disclosed |
| CN-1184474-A | Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease | VERTEX PHARMA (US) | 1998-06-10 | — | — | CN | disclosed |
| EP-0833826-A1 | OXYGENATED-HETEROCYCLE CONTAINING SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | Vertex Pharmaceuticals Incorporated (US) | 1998-04-08 | — | — | EP | disclosed |
| US-5691372-A | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1997-11-25 | — | — | US | disclosed |
| WO-1996033187-A1 | OXYGENATED-HETEROCYCLE CONTAINING SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1996-10-24 | — | — | WO | disclosed |
| WO-1995024385-A1 | SULPHONAMIDE DERIVATIVES AS ASPARTYL PROTEASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1995-09-14 | — | — | WO | disclosed |