Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methamphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.81 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.81 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.81 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methamphetamine SCHEMBL7036430 | 0.92 | SIGMAR1 (0.81) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL7036433 | 0.92 | SIGMAR1 (0.81) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL27438559 | 0.92 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL28233460 | 0.91 | SIGMAR1 (0.78) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL18227057 | 0.90 | SIGMAR1 (0.91) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL15094315 | 0.90 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Levmetamfetamine SCHEMBL727412 | 0.90 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL42615 | 0.90 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL13747483 | 0.90 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL20211416 | 0.90 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118076892-A | Blood cell separating agent for analysis and blood cell separating method | 日东纺绩株式会社 | 2024-05-24 | — | — | CN | disclosed |
| CN-112566697-B | Pyrrolo [1,2-b ] pyridazine derivatives as IRAK4 inhibitors | 吉利德科学公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-112566915-B | Thiadiazole IRAK4 inhibitors | 吉利德科学公司 | 2024-04-09 | — | — | CN | disclosed |
| CN-117587645-A | Reaction liquid for pigment printing and dyeing, ink set and recording method | 精工爱普生株式会社 | 2024-02-23 | — | — | CN | disclosed |
| CN-112533924-B | Pyrrolo [1,2-b ] pyridazine derivatives as IRAK4 inhibitors | 吉利德科学公司 | 2023-11-28 | — | — | CN | disclosed |