SCHEMBL2911366

SCHEMBL2911366

CCN1CCN(c2cc3c(Nc4ccc(Cl)c(Cl)c4)c(C(N)=O)cnc3cc2OC)CC1

nearest known ligand 0.83

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 19/20 0.83
KCNH2 Q12809 1/20 0.56
SCN5A Q14524 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2910745 0.93 CSF1R (0.72) CSF1RKCNH2SCN5A
SCHEMBL2905491 0.91 CSF1R (1.00) CSF1RKCNH2SCN5A
SCHEMBL2913908 0.90 CSF1R (0.68) CSF1R
SCHEMBL2909935 0.90 CSF1R (0.85) CSF1R
SCHEMBL2904973 0.89 CSF1R (0.83) CSF1RKCNH2SCN5A
SCHEMBL2912117 0.88 CSF1R (0.83) CSF1RKCNH2SCN5A
SCHEMBL2911370 0.88 CSF1R (0.94) CSF1RKCNH2SCN5A
SCHEMBL2904695 0.87 CSF1R (1.00) CSF1RKCNH2SCN5A
SCHEMBL2904777 0.86 CSF1R (0.64) CSF1RKCNH2SCN5A
SCHEMBL2913800 0.86 CSF1R (0.78) CSF1RKCNH2SCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2010496-B1 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS ASTRAZENECA AB (SE) 2010-08-25 EP disclosed