Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | THRB | P10828 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913852 | 0.88 | CSF1R (0.59) | MAPTTHRBGAACA2TP53 | |
| SCHEMBL2907504 | 0.86 | MAPT (0.56) | MAPTTHRBGAACA2TP53 | |
| SCHEMBL2910243 | 0.86 | CSF1R (0.59) | MAPTTHRBGAACA2TP53 | |
| SCHEMBL2912424 | 0.86 | CSF1R (0.59) | MAPTTHRBGAACA2TP53 | |
| SCHEMBL2911838 | 0.85 | MAPT (0.63) | MAPTTHRBGAACA2TP53 | |
| SCHEMBL2911785 | 0.85 | MAPT (0.53) | MAPTTHRBGAACA2TP53 | |
| SCHEMBL2910646 | 0.85 | MAPT (0.56) | MAPTTHRBGAACA2TP53 | |
| SCHEMBL2904987 | 0.84 | MAPT (0.54) | MAPTTHRBGAACA2TP53 | |
| SCHEMBL2912397 | 0.84 | CA2 (0.61) | MAPTTHRBGAACA2TP53 | |
| SCHEMBL2908274 | 0.84 | CA2 (0.61) | MAPTTHRBGAACA2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |