SCHEMBL291158

SCHEMBL291158

O=c1cc(-c2ccccc2Cl)oc2c(C3CCNC3CCO)c(O)cc(O)c12

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 14/20 0.64
CDK1 P06493 14/20 0.64
CCND1 P24385 12/20 0.64
CCNB1 P14635 11/20 0.64
CCNB2 O95067 8/20 0.64
CCNB3 Q8WWL7 8/20 0.64
CDK2 P24941 9/20 0.62
CDK9 P50750 8/20 0.62
CCNT1 O60563 7/20 0.62
CCNA2 P20248 5/20 0.62
CCNE1 P24864 4/20 0.62
GSK3A P49840 4/20 0.62
CDK6 Q00534 4/20 0.62
CDK7 P50613 3/20 0.62
CCND3 P30281 3/20 0.62
CCNH P51946 2/20 0.62
MNAT1 P51948 2/20 0.62
MAPK15 Q8TD08 2/20 0.62
CAMKK2 Q96RR4 2/20 0.62
CCNA1 P78396 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16722415 1.00 CDK4 (0.64) CDK4CDK1CCND1CCNB1CCNB2
Hydrochloric Acid SCHEMBL6120022 0.99 CDK4 (0.62) CDK4CDK1CCND1CCNB1CCNB2
Hydrochloric Acid SCHEMBL17294474 0.99 CDK4 (0.62) CDK4CDK1CCND1CCNB1CCNB2
Hydrochloric Acid SCHEMBL14150486 0.86 CDK4 (0.48) CDK4CDK1CCND1CCNB1CCNB2
Hydrochloric Acid SCHEMBL6120668 0.86 CDK4 (0.64) CDK4CDK1CCND1CCNB1CCNB2
SCHEMBL8515827 0.84 CYP1A1 (0.49) CDK4CDK1CCND1CCNB1CCNB2
Hydrochloric Acid SCHEMBL14150482 0.82 CDK4 (0.62) CDK4CDK1CCND1CCNB1CCNB2
SCHEMBL7829623 0.82 CDK4 (0.64) CDK4CDK1CCND1CCNB1CCNB2
SCHEMBL4585801 0.82 CDK4 (0.64) CDK4CDK1CCND1CCNB1CCNB2
Hydrochloric Acid SCHEMBL4447778 0.81 CDK4 (0.65) CDK4CDK1CCND1CCNB1CCNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2640380-A1 PHARMACEUTICAL COMBINATION OF PACLITAXEL AND A CDK INHIBITOR Piramal Enterprises Limited (IN) 2013-09-25 EP disclosed
WO-2012069972-A1 A PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF BREAST CANCER PIRAMAL LIFE SCIENCES LIMITED (IN) 2012-05-31 WO disclosed
WO-2012066508-A1 PHARMACEUTICAL COMBINATION OF PACLITAXEL AND A CDK INHIBITOR PIRAMAL LIFE SCIENCES LIMITED (IN) 2012-05-24 WO disclosed
EP-2427188-A1 PYRROLIDINE-SUBSTITUTED FLAVONES AS RADIO-SENSITIZERS FOR USE IN THE TREATMENT OF CANCER Piramal Life Sciences Limited (IN) 2012-03-14 EP disclosed
WO-2010128443-A1 PYRROLIDINE-SUBSTITUTED FLAVONES AS RADIO-SENSITIZERS FOR USE IN THE TREATMENT OF CANCER PIRAMAL LIFE SCIENCES LIMITED (IN) 2010-11-11 WO disclosed