Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 20/20 | 0.35 |
| ▸ | MMP13 | P45452 | 3/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.35 |
| ▸ | MMP2 | P08253 | 4/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29116573 | 0.82 | ADAMTS5 (0.37) | ADAMTS5MMP13ADAM17MMP2ADAMTS4 | |
| SCHEMBL24728831 | 0.82 | ADAMTS5 (0.35) | ADAMTS5MMP13ADAM17MMP2ADAMTS4 | |
| SCHEMBL29893273 | 0.82 | ADAMTS5 (0.35) | ADAMTS5MMP13ADAM17MMP2ADAMTS4 | |
| SCHEMBL23745440 | 0.81 | ADAMTS5 (0.39) | ADAMTS5MMP13ADAM17MMP2ADAMTS4 | |
| SCHEMBL24728764 | 0.80 | ADAMTS5 (0.36) | ADAMTS5MMP13ADAM17MMP2ADAMTS4 | |
| SCHEMBL24728769 | 0.80 | ADAMTS5 (0.36) | ADAMTS5MMP13ADAM17MMP2ADAMTS4 | |
| SCHEMBL29892226 | 0.79 | ADAMTS5 (0.36) | ADAMTS5MMP13ADAM17MMP2ADAMTS4 | |
| SCHEMBL24729211 | 0.79 | ADAMTS5 (0.36) | ADAMTS5MMP13ADAM17MMP2ADAMTS4 | |
| SCHEMBL29892549 | 0.79 | ADAMTS5 (0.36) | ADAMTS5MMP13ADAM17MMP2ADAMTS4 | |
| SCHEMBL23745400 | 0.78 | ADAMTS5 (0.56) | ADAMTS5MMP13ADAM17MMP2ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136051-A | Prodrugs of ADAMTS inhibitors, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-11-28 | — | — | CN | disclosed |